The finding that np14 mutant yeast cells are defective in nuclear protein import and have nuclear envelope structural abnormalities suggests that Np14p helps to maintain nuclear envelope integrity 16.

The nuclear envelope is a structure that surrounds and defines the nucleus and separates it from the cytoplasm. It is comprised of inner and outer membranes separated by the perinuclear space, ...

Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS. Journal of Cell Biology , 2022; 221 (12) DOI: 10.1083/jcb.202201024 Cite This Page : ...

Using a membrane-based yeast two-hybrid assay, which could detect interactions at the nuclear envelope, Chen found that Ndc1 bound to a protein called Mps3.

More information: Giel Korsten et al, Nuclear poly-glutamine aggregates rupture the nuclear envelope and hinder its repair, Journal of Cell Biology (2024). DOI: 10.1083/jcb.202307142 Journal ...