which targeted the SIRPα receptor with which CD47 interacts. Last year, AbbVie also pulled out of a $1.3 billion R&D partnership with I-Mab on lemzoparlimab for MDS and AML, for undisclosed ...

Target engagement increased in a dose-dependent manner, with CD47 receptor occupancy ranging up to 100% at the highest doses evaluated. ACC Abstract Details The poster presentation will be ...

In reality, however, only apoptotic cells are engulfed, apparently because their surface ligand CD47 is prevented from activating the inhibitory phagocyte receptor SIRPα. Figure 2: Formation of a ...

"This immune-stimulating ATC concept extends beyond CD47, and we are already developing projects that target other ...

When the researchers transplanted tissue from one mouse into a host animal with different SIRP-alpha receptors, the molecule bound to the CD47 receptor on ... Lab safety rules dictate that one must ...