ASCL1 Protein Helps Drive the Transition to NEPC Using this new tool, his team has already made one key discovery: The transition from adenocarcinoma to NEPC depends on a protein called ASCL1.

Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes. Cell Stem Cell, 2022; 29 (10): 1491 DOI: 10.1016/j.stem.2022.09.006 ...

Since Ascl1 activated cardiomyocyte genes, the researchers added it to the three-transcription-factor cocktail they had been using for making cardiomyocytes, to see what would happen.

Soon they determined that this activation was due to Ascl1, one of the master-programmer “transcription factor” proteins that had been used to make the neurons. Since Ascl1 activated cardiomyocyte ...

There were errors in two sentences within the section 'Epigenetic changes in SCLC', indicating that EZH2 suppresses ASCL1 expression by suppression of TGFβ signalling. Instead, EZH2 promotes ...

The team led by the research director Ryoichiro Kageyama, professor at Kyoto University and one of its group leader Dr. Hiroshi Kori at Ochanomizu University have found by time-lapse imaging that the ...

The researchers added Ascl1 to the three transcription factor cocktails they had been using to create cardiomyocytes to see what would happen because Ascl1 activated cardiomyocyte genes.