Chimeric antigen receptor T (CAR-T) cells are native T lymphocytes genetically modified to express a receptor designed to recognize a specific tumoral antigen and eliminate tumoral cells. CD19 CAR-T ...

In the largest study of its kind, researchers from The University of Texas MD Anderson Cancer Center identified three subgroups of patients with large B-cell lymphoma (LBCL) who have different ...

In this study, we assessed the safety, feasibility, and preliminary efficacy of huCART19-IL18 in patients with relapsed or refractory lymphoma after previous anti-CD19 CAR T-cell therapy. Using a ...

Patients and Methods We treated 15 patients with advanced B-cell malignancies. Nine patients had diffuse large B-cell lymphoma (DLBCL), two had indolent lymphomas, and four had chronic lymphocytic ...

In some cases, that target is CD19, which is just the name of a protein on the surface of B cells, other immune cells. Those B cells can become malignant or cancerous, and so we treat B-cell ...

To address limitations with CAR T therapies targeting CD19, Allogene Therapeutics Inc. has developed ALLO-329, a CD19/CD70-targeting CAR therapy that is able to deplete activated alloreactive ...

Qiong Fu presented on GC012F (AZD0120) - a CD19/B cell maturation antigen (BCMA) dual-targeting CAR-T evaluated in 10 patients with SLE. At Month 9, 70% had been able to stop glucocorticoids and ...

A “complete eradication” of B cells with chimeric antigen receptor T-cell therapy is responsible for the long-term, drug-free remission from autoimmune diseases observed after treatment ...

4 Clinicaltrials.gov. A Phase 1b Multicenter, Open-Label, Study of JNJ-90014496, an Autologous CD19/CD20 Bi-specific CART-Cell Therapy in Adult Participants With B-Cell Non-Hodgkin Lymphoma.

We conducted a phase 1b–2 multicenter study of obe-cel in adults (≥18 years of age) with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). The main cohort, cohort 2A, included ...