Novel combination achieves 60.8% response rate and 90.2% disease control rate in first-line non-small cell lung cancer (1L ...

Complementary nature of these two immunotherapies leads to excellent 17.6-month median Overall Survival in head and neck cancer patients with PD-L1 CPS 1; Mature overall survival ...

CD4 + T cell and CD8 + T cell responses and their pathogenic potential through a focus on specific objectives that can be addressed in humanized mice, including mice that have human islets, MHC ...

IL-21 is primarily produced by CD4+ T cells, particularly follicular helper T (Tfh ... IL-21, Interleukin-21; Tfh cells, Follicular helper T; Th17, T helper 17; MHC, Major Histocompatibility Complex; ...

The neonatal Fc receptor (FcRn) is a developmentally regulated, major histocompatibility complex class I –related molecule that binds IgG and albumin in a pH-dependent manner. FcRn protects IgG ...

Both the naive T- and B-cell receptor repertoire are generated by interaction with self-ligands, such as the major histocompatibility complex (MHC), which in turn can signal to T- and B-cells to ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T ...

The decrease in CD4 cells during HIV infection seems to be ... and higher LPS levels were associated with greater activation of CD8 + lymphocytes. CD8 + activation also was found to be higher ...

Antigen-presenting cells (APCs), such as dendritic cells and macrophages, are essential for initiating and regulation of anti-tumor T cell responses.

Biomarkers such as CD4, CD8, PD-L1, FOXP3, and CK AE1/3 are critical for understanding T-cell biology and tumor-immune interactions. Traditional immunofluorescence (IF) and immunohistochemistry (IHC) ...

et al. Influence of lifelong cumulative HIV viremia on the long-term recovery of CD4+ count and CD4+/CD8+ ratio among patients on combination antiretroviral therapy. AIDS. 2015;29(5):595-607. DOI: ...