Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance.

T cell tolerance to self-antigens is considered to reflect a combination of central and peripheral tolerance 1,2,3,4,5.Central tolerance leads to deletion of immature T cells in the thymus and is ...

More information: Elif Çakan et al, TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance, Journal of Experimental Medicine (2023). DOI: 10.1084/jem.20230944 .

New studies reveal that a learned compensatory response can trigger "drug tolerance," a physiological process central to addiction. Drug tolerance makes people need more and more drug to get the ...

Signaling molecules involved in central tolerance were inhibited; upon closer examination, the scientists saw that this stemmed from CXCL4 binding to and preventing the delivery of DNA fragments ...