Nuclear magnetic resonance (NMR) spectroscopy is a technique that detects the chemical environment of atomic nuclei by the absorption of radio-frequency electromagnetic radiation when in the ...

Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

Solution-state nuclear magnetic resonance (NMR) spectroscopy is the classical NMR spectroscopy approach used for molecular structure determination, where the experimental sample is studied while ...

Medicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, Magyar tudósok krt. 2, 1117 Budapest, Hungary National Drug Research and Development Laboratory, HUN-REN Research ...

2010). Ongoing drug discovery is necessary for identifying effective, safe, and affordable cures for an expanding spectrum of human ailments. As the treatment of these diseases has serious safety and ...

The 1H NMR spectra were measured on an MECUYR-VX300 spectrometer. The UV–vis absorption spectra were recorded on a Shimadzu UV-2500 recording spectrophotometer. Ultraviolet and UPS measurements were ...

Thus, Cdk5 represents a prime target for treatment in a spectrum of neurological and neuropsychiatric conditions. While intracranial infusions or treatment of acutely dissected brain tissue with ...

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Department of Chemistry, University of California, Irvine, Irvine, California 92697, United States ...