During EMT, epithelial-derived tumor cells lose their epithelial characteristics and acquire mesenchymal traits, resulting in reduced intercellular adhesion, loss of cell polarity, and increased cell ...

Abstract Invasive cancer is defined by the loss of epithelial cell traits resulting from the ectopic expression of epithelial-mesenchymal transition (EMT)-related transcription factors such as Snail.

Epithelial-mesenchymal transition (EMT) is critical for tumor invasion and many other cell-relevant processes. While much progress has been made about EMT, no report concerns the EMT of cells on ...

When epithelial tumors progress, they lose cell-cell contacts and apico-basal polarity, transforming into spindle-shaped mesenchymal structures in order to a ...

Integrated live cell imaging and image analyses in the framework of transition path theories identify epithelial-to-mesenchymal transition proceeds through parallel paths.

Cancer metastasis leads to most deaths in cancer patients, and the epithelial–mesenchymal transition (EMT) is the key mechanism that endows the cancer cells with strong migratory and invasive ...

Here, we construct a topographic map underlying epithelial–mesenchymal transitions using a combination of numerical simulations of a Boolean network model and the analysis of bulk and single-cell gene ...

Epithelial–mesenchymal transition refers to a dynamic change, wherein epithelial cells lose their polarity and adherence and acquire migratory function and fibroblast features.

Endothelial cells (EC) have many epithelial characteristics, including strong apical–basal polarity, the ability to form tubes, and the potential to undergo a transition to a mesenchymal-like cell ...

ABSTRACT: Objectives: Cell polarity and epithelial morphology are peculiar features of cells forming the terminal ductal lobular unit, and they are early lost during neoplastic transformation because ...

Hence, how loss of cell polarity in epithelial cells may promote epithelial mesenchymal transition and metastasis will also be discussed.