Across many cancers, mortality is associated with metastasis and acquired drug resistance, both of which often manifest in recurrent disease. Central to these phenomena is epithelial to mesenchymal ...

A potential explanation for this discrepancy is the possible loss of epithelial differentiation and the acquisition of epithelial-mesenchymal transition (EMT). Thus, we assessed CTC gene profile in ...

Researchers define for the first time the tumor transition states occurring during cancer progression and identify the tumor cell populations responsible for metastasis.

The presence of epithelial-mesenchymal transition (EMT) in breast cancer (BC) cells has been linked to worse prognosis and may influence response to systemic treatment. We explored the effect of EMT ...

This new article publication from Acta Pharmaceutica Sinica B , discusses how a psychological stress-activated NR3C1/NUPR1 ...

During embryonic development, the process of epithelial-mesenchymal transition (EMT) allows the migration of cells to different destinations to form organs and tissues. This same program is used ...

Researchers at Karolinska Institutet, led by Dr. Helin Norberg and Dr. Erik Norberg, have identified a previously unknown mechanism that affects the ability of cancer cells to spread in the body. The ...

The switch that many cancer cells use to become metastatic is the circuit that governs the epithelial-to-mesenchymal transition, or EMT.

Studying this process, known as epithelial-to-mesenchymal transition (EMT), in a developmental context can help shed light on EMT in cancer metastasis. Photo courtesy of the Hadjantonakis Lab.

Different mechanisms have been proposed to account for tumor heterogeneity such as epithelial to mesenchymal transition (EMT), a process in which epithelial tumor cells loose their adhesion and ...