In this valuable study, the authors provide a simple yet elegant approach to identifying therapeutic targets that synergize to prevent therapeutic resistance in ovarian cancer using cell lines, ...

The economic dispatch of microgrids presents significant challenges, particularly in managing demand response. This study addresses the limitations of deep reinforcement learning (DRL) in strictly ...

G proteins are named for their ability to bind the nucleotides GTP and GDP. They act as molecular switches in transduction of intracellular signaling: when G proteins are bound to GTP, they are active ...

Intercellular fluid flow, not just cell structure, governs how tissues respond to physical forces by Jennifer Chu, Massachusetts Institute of Technology ...

Decoding the response and resistant features to the Claudin18.2-specific CAR-T cell CT041 in gastric cancer: A multi-omics exploratory biomarker analysis of the phase 1 clinical trial.

Within the NIVO+CABO arm, this integrative model uncovered high VICM (and therefore anti-tumor macrophage polarization), high PD-L1 staining, high plasma cell numbers and high cancer cell numbers at ...

Following this experiment, the researchers analyzed the effect of sound on cells using RNA-sequencing, microscopy, and other methods. Their results revealed cell-level responses to the audible ...

Cold water immersion for seven days significantly improves cellular resilience and autophagic function, helping cells manage stress better. This adaptation could enhance health and longevity ...

Since 2021, we have been organizing ourselves as a community of researchers in systems biology and related fields, and interested in fundamental questions around cell physiology, cellular growth, ...

Small GTPases are key regulators of many cellular processes. They are known to function as molecular switches that change between GTP- and GDP-bound states to regulate downstream events. Here, we ...