In astrocytes exposed to 1 μM synthetic oligomeric Aβ42 for five days, the urea cycle revved up twofold. In particular, the enzyme ornithine decarboxylase 1 (ODC1) was elevated, converting ornithine ...

More information: Yiming Zhang et al, Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism, Cell Metabolism (2024). DOI: 10.1016/j ...