Proteins are life's molecular workhorses, doing everything from turning sunlight into food to fighting viruses. They are ...

The natural protein universe is vast, and yet, going beyond and designing new proteins not observed in nature can yield new ...

Protein folding is the process by which proteins achieve their mature functional (native) tertiary structure, and often begins co-translationally. Protein folding requires chaperones and often ...

Technological advances in proteomics, including sample separation, mass spectrometry, and searching algorithms, have empowered in-depth discovery of protein post-translational modifications from ...

Proteins that fold over free-energy barriers ≤ 3RT are classified as downhill folders. This regime is characterized by equilibrium unfolding that is proportionally broader and more complex the lower ...

Here, we describe an all-atom protein generative model, Protpardelle, which codesigns the backbone, sequence, and sidechains of a protein together. Our method enables a key capacity in protein design: ...