"We observed that the STRESS UP gene signature is linked to various critical stages of cancer development including: tumor ...

Precancerous cells must adapt to and overcome cellular stress and inflammation in order to progress and form malignant tumors.

Relative to existing gene signatures, the STRESS signature better predicted not only whether cells would later develop into ...

Conclusion Single-cell sequencing with pancreatic immune cells in human CP highlights pancreas-specific immune crosstalk through the CCR6-CCL20 axis, a signalling pathway that might be leveraged as a ...

Pancreatic cancer can be hard to spot in the early stages. Symptoms include jaundice, pain, and weight loss. Learn more about the symptoms and treatments here.

Despite the high prevalence of type 2 diabetes (T2D), the mechanisms driving pathology in pancreatic islet β cells remain poorly understood. We utilized a multiomics approach to evaluate the ...

The breakthrough involved printing human islets – the insulin-producing clusters of cells in the pancreas – using a customised bioink made from alginate and decellularised human ...