Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection. Science Immunology, 2022; 7 (68) DOI: 10.1126/sciimmunol.abl6322; ...

Feinerman O, Jentsch G, Tkach KE, et al: Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response. Mol Syst Biol 6:437, 2010. ...

T cells are completely activated by the first and second signal stimulation, which are contingent on a range of various cytokines (IL-1, IL-2, IL-4, IL-6, IL-10, IL-12, IL-15 and IFN-γ, etc.) for ...

These secondary signals are necessary for T cell activation and require the engagement of proteins on T cells, such as CD28, and other proteins on APCs, including the CD80/CD86 complex. Signal 2 ...

Researchers uncover a second activation phase in T cells, offering new hope for vaccines and immunotherapies targeting infections and cancer. ... This occurs in specific lymph node areas that are ...

Interleukin-2 (IL-2) inhibitors are immunosuppressive agents that block the activity of IL-2, a cytokine involved in the activation and proliferation ...

Researchers from UCLA published a Perspective in Science Bulletin proposing bioengineered platforms that mimic immunological synapses to improve CAR-T cell manufacturing. Their strategies offer ...

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation. Nature Genetics, 2022; DOI: 10.1038/s41588-022-01066-3; Cite This Page: MLA; APA; Chicago; ...

Since the 1980s, oncologists have known that high doses of IL-2 enable T-cells to overcome these barriers, and the cytokine has been used as cancer therapy in challenging cancer cases. But simply ...

The scientists could show that in this second phase, T cells re-cluster with DCs and get activated again to enhance their proliferation and specialization. This occurs in specific lymph node areas ...