Generic ionic models optimized to replicate experimentally recorded cardiac action potentials (APs) from the central and peripheral sinoatrial node (SAN), the natural pacemaker of the heart, as well ...

We were interested in whether this strategy would be applicable to the design of LIMK1-selective tool compounds. To develop a covalent inhibitor, we therefore synthesized a series of LIMK-i3-based ...

Researchers have also explored serine in their efforts to develop selective monoacylglycerol lipase inhibitors based on an azetidin-2-one motif. They were able to confirm covalent binding via X-ray ...

However, almost all models only identified metabolic pathway types of compounds rather than actual metabolic pathways. This study proposed a novel model for predicting actual metabolic pathways for ...