The cyclin-dependent kinase (Cdk) inhibitor p27 (also known as KIP1) regulates cell proliferation, cell motility and apoptosis. Interestingly, the protein can exert both positive and negative ...

CKIs (p27 KIP1 and p21 CIP1) bind to and inhibit the activation of cyclin CDK complexes. Therapeutic approaches to vascular proliferative diseases are shown in orange. CDC2, cell division cycle 2.

The p27 KIP1 gene is located at 12p12-13.1. [103, 104, 105, 106, 107] Normal human prostate tissue has been shown to produce abundant amounts of p27 protein and high levels of p27 KIP1 mRNA levels.