To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T ...

The study reveals how APOL9 selectively binds to gut bacteria, enhancing immune responses and maintaining intestinal health ...

The human gut is home to trillions of microbes that not only aid in digestion, but also play a key role in shaping our immune ...

The study by Li et al. provides fundamental findings supported by convincing evidence that they defined cellular reprogramming of androgen receptor in neuroendocrine prostate cancer (NEPC). The ...

The human gut is home to trillions of microbes that not only aid in digestion but also play a key role in shaping our immune ...

Study in mice shows how a host-elicited factor benefits gut immunological homeostasis by selectively targeting commensal ceramide molecules.

The human gut is home to trillions of microbes that not only aid in digestion but also play a key role in shaping our immune system. These microbes ...

TREM2 signaling may keep neuronal hyperexcitability in check ... In de Weerd’s study, these included galectin-3, SPP1, IFN-γ, MHC II, Cxcl10, and others involved in antigen presentation and immune ...

Antigen-presenting cells (APCs), such as dendritic cells and macrophages, are essential for initiating and regulation of anti-tumor T cell responses.

We provided the first direct evidence that endogenous TGF-ß1 controls developmental expression of both class I and class II MHC antigens ... The phenotype of our Smad3-null mouse links signaling ...

This situation carries important therapeutic implications in that it may be difficult to treat or prevent T1D by blocking only one cytokine or signaling ... the NOD H-2 g 7 MHC but that lack ...