In addition, SYS6051 had improved resistance towards retro-Michael elimination reactions, resulting in improved stability compared to cysteine thiol-maleimide conjugated ADCs. The naked SYS6051-mAb ...

Click chemistry efficiently ligates molecular building blocks in a robust and high-yielding manner and has found major application in the rapid modification of important molecular actors in biological ...

Department of Metallurgical, Materials, and Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States Department ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Adenylate kinase 2 (AK2) is localized in the ...

We thank J. Davis for letting us use his fluorometer, R. Padua for structural advice, D. Sabatini for advice on the manuscript, and E. Friedenthal; A. Longanathan; T. Clark; and M. Karkoski for ...

PermaLink® offers a simple, scalable and highly stable bioconjugation method as an alternative to maleimide-based conjugation, enabling highly stable ADCs with favourable anti-tumour activity and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neurotoxins derived from animal venoms are ...

There are still thousands of possible answers, of course, but it means the answer will never be a word as obscure as, say, "THIOL", or "CAIRD", or "MALIC" (yes, those are all real words). There are ...