A study from EPFL reveals why humans excel at recognizing objects from fragments while AI struggles, highlighting the ...

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Unprocessed Okazaki fragments during replication can lead to genomic instability and replication defects (16, 41, 44, 45). PAR synthesis or PARP activity is detected in normal unperturbed cells during ...

The replisome does not generate Okazaki fragments on the 3’ overhang; it actually stops lagging-strand synthesis long before the leading strand reaches the 5’ end.

For example, they observed 2 that the Okazaki fragments were longer in mutant strains defective in CAF-1, a protein complex known 5 to act as a histone chaperone, which promotes histone deposition ...

Joining of the Okazaki fragments involves additional enzymes, such as FEN1 and DNA ligase. Synthesis of the leading strand is likely attributable to Pol ε (blue). Potential mismatches created by Pol α ...