Pancreatic cancer, which was predicted to become the second leading cause of cancer death as early as 2015, eludes treatment for several reasons, not the least of which is tumor heterogeneity. For ...

Cancer immunotherapy has transformed the treatment landscape by helping the immune system recognize and attack tumors. At the ...

Oncolytics Biotech® Inc. (Nasdaq: ONCY) (TSX: ONC), a leading clinical-stage company specializing in immunotherapy for ...

Pancreatic tumors span the spectrum of T cell infiltration, but the basis for this heterogeneity is poorly understood. In this study, the Penn team created a library of pancreatic tumor cell lines ...

"Pancreatic cancer is what is known as a 'cold tumor,' meaning it has few infiltrated immune cells and therefore immunotherapy usually does not work," argues Rovira.

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. The disease is almost always fatal, with a 10-year survival rate of around 1 percent.

For many types of cancer, including breast, ovarian, prostate and pancreatic cancers, the resulting tumors are “cold,” meaning they don't trigger an immune response and continue causing harm ...

So-called "hot" tumors filled with T cells are often considered to be more sensitive to immunotherapy compared to "cold" tumors with fewer T cells, but a clear demonstration of why has eluded ...

The scientists used genetic editing to turn off the production of KRT19 or TGM2 in mouse pancreatic tumors. Without KRT19 or TGM2, the cancer cells lost the CXCL12-KRT19 protection and T cells ...

A new study that analyzed the tumor microenvironment of pancreatic cancer revealed the cause of tumor cell resistance to immunotherapy and resulted in new treatment strategies.

Tumors change over time, and in an ideal world, a doctor would derive multiple organoids as the cancer evolved. But Hidalgo thinks some findings will be generalizable across a single patient’s ...

Pushing past pancreatic tumors’ defenses Date: February 16, 2022 Source: Cold Spring Harbor Laboratory Summary: Researchers found that some cancer cells weave a deactivating signal into a ...