WB-PBPK modeling simulates pharmacokinetic profiles on the basis of drug-related physicochemical properties, clearance and a set of relevant physiological parameters, such as organ volumes, tissue ...

Pharmacokinetics and Pharmacodynamics of Intranasal Versus Intravenous ... The pharmacokinetics of intravenous fentanyl reflected a 2-compartment model with a clearance of approximately 1.5 L ...

This is similar to clearance estimates (0.055–0.075 l/h/kg) reported following intravenous tacrolimus to 31 adult HCT patients. 11 Tacrolimus pharmacokinetics were also evaluated in seven ...

Pharmacokinetics were assessed by noncompartmental and model-dependent methods. Pharmacodynamic correlations were evaluated statistically and by regression models. Results. Paclitaxel disposition is ...