A new artificial intelligence model can improve the process of drug and vaccine discovery by predicting how efficiently ...

Without the receptor, ADGRG1, the microglia barely nibbled on the toxic protein. Using a mouse model of Alzheimer’s disease, the researchers observed how the loss of ADGRG1 led to the rapid buildup of ...

These Immune Cells Eat Molecular Trash to Keep Alzheimer's at Bay UCSF scientists have discovered how microglia engulf and break down amyloid beta, a protein that builds up in Alzheimer’s, with ...

The natural protein universe is vast, and yet, going beyond and designing new proteins not observed in nature can yield new ...

The structural similarities between protein sequences and natural languages have led to parallel advancements in deep learning across both domains. While large language models (LLMs) have achieved ...

Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells.

In this valuable study, the authors provide a simple yet elegant approach to identifying therapeutic targets that synergize to prevent therapeutic resistance in ovarian cancer using cell lines, ...

Contrary to long-standing assumptions, human egg cells stay pristine for decades not by ramping up waste disposal, but by ...

A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.

Understanding the interaction between compounds and proteins is a crucial step in the process of discovering and developing drugs. To assist biologists and medicinal chemists, predicting ...

Every living cell must interpret its genetic code—a sequence of chemical letters that governs countless cellular functions. A new study by researchers from the Center for Theoretical Biological ...