At higher magnification these foamy macrophages were easily apparent in the pulmonary airspaces (arrowhead) and in the alveolar walls (arrows) of the ASMKO lungs compared with normal mice .

More information: Huachun Cui et al, TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity, Nature Communications (2025). DOI: 10.1038/s41467-025-57024-0 ...

COPD study links increased alveolar macrophage carbon to worse lung function, inflammation, and altered cell phenotype.

Looking specifically at alveolar macrophage cells under a microscope, the researchers measured the sizes of the cells and the amount of carbon accumulated in the cells. They found that the average ...

Levels of macrophage colony-stimulating factor (M-CSF), which has regulatory effects on myeloid cells that overlap with the regulatory effects of GM-CSF, are increased in patients with pulmonary ...

James Baker, Sophie Booth, Josiah Dungwa, Andrew Higham, Dave Singh, Simon Lea. Alveolar macrophage carbon is associated with COPD severity. ERJ Open Research , 2025; 00933-2024 DOI: 10.1183 ...

To the Editor: Vassallo et al. (June 29 issue)1 depict a central role for the alveolar macrophage in the pathogenesis of pulmonary Langerhans'-cell histiocytosis. We made several observations in a ...

The study found that COPD patients’ alveolar macrophages — a type of lung cell that removes dust, particles and microorganisms from the lungs — contain more carbon than those of smokers. The ...

TREM2, a cell surface receptor on monocyte-derived alveolar macrophages (Mo-AMs), is highly expressed in fibrotic lungs and promotes macrophage survival and lung fibrosis by delaying apoptosis.