In this valuable study, the authors provide a simple yet elegant approach to identifying therapeutic targets that synergize to prevent therapeutic resistance in ovarian cancer using cell lines, ...

A study led by Samer Srour, MB, ChB, MS, focuses on AIC100, a novel third-generation CAR T-cell therapy specifically engineered to target ICAM-1 (Intercellular Adhesion Molecule-1), a protein ...

These CAR-T cells showed antigen-dependent activation, effectively killing GUCY2C-expressing cancer cells in vitro and providing long-term protection in mouse models against lung metastases of CRC. 39 ...

In this study, we first identified a functional TCR, Tcr-1, which selectively recognized the SYT-SSX fusion neoantigen shared by most synovial sarcomas. Engineered T-cell expressing Tcr-1 (Tcr-T1) ...

Together, these results show that Artificial Targets induce CAR T cell proliferation in an antigen-specific manner, and underscore the benefit of using Artificial Targets for functional ...

Oxygen levels at the time of T cell activation are major determinants of function, even when T cells are subsequently expanded in high levels of oxygen.

In this article, ACROBiosystems discuss the importance of T cells in the immune response and shares some essential tips and methods for culturing T-cells efficiently and effectively.

Alternatively, autologous T cells can be engineered in vitro to become tumor-reactive by the introduction of genes that encode receptors specific for tumor antigens (either T-cell receptors [TCRs ...

We demonstrate the direct causality between microvilli formation and altered gene expression in T cells. We discover that the size of the microvilli critically influences T cell receptor agonistic ...

We demonstrate that the addition of IL-4 after antigen stimulation drives the expansion of T cell clones encoding unique receptor sequences. We show that our approach represents a scalable, ...

The recent rise of adoptive T cell therapy (ATCT) as a promising cancer immunotherapy has triggered increased interest in therapeutic T cell bioprocessing. T cell activation is a critical processing ...