In normal cells, genomic lesions occur naturally during DNA replication as part of the cell cycle, ... telomere DNA-ADPr is highly dynamic and subject to stringent control by TARG1. ...

When copying the telomere, leading-strand DNA replication should copy the CCCTAA repeats to generate the TTAGGG repeat strand, while lagging-strand synthesis should do the opposite, making new ...

Wistar Institute have published the first detailed report on the structure and function of a crucial domain in the protein known as Cdc13, which sustains telomeres by clamping to DNA and ...

Telomeres play an essential role in determining how many times a cell can divide. These repetitive sequences of DNA are located at the ends of chromosomes, structures that contain genetic information.

A s DNA strands ravel and unravel in an intricate dance, one notable event takes center stage: replication. This process is essential to life, but the finer details of its orchestrated steps are still ...

In normal cells, genomic lesions occur naturally during DNA replication when a cell divides, ... leading to disruption of telomere replication and premature telomere shortening.

To show that these telomere defects were due to modification of telomeric DNA, O'Sullivan and his team took bacterial enzymes that function similarly to PARP1 and put them into human cells.

Telomeres are found at the end of chromosomes and help to mitigate the loss of DNA from the ends of these chromosomes during DNA replication. Telomere shrinking is a natural process that leads ...

For the first time, scientists have shown that a major protein acts as a direct block in multiple stages of DNA replication, improving our understanding of how cancer develops. Researchers studied the ...