The Food and Drug Administration has granted Fast Track designation to bempikibart for the treatment of alopecia areata.

Improper self-antigen recognition by DCs and T-cell initiates ... are known to drive physiological selection of Th1 or Th2 pathways. A perturbation in immune receptor signaling may underlie ...

Analysis of TCR-mediated signaling pathways revealed normal early T cell activation. However ... 10µg/ml of anti-IL-4 and, 20 U/ml of IL-2); Th2 (10 ng/mL of IL-4, 10 µg/ml of anti-IFNγ and, 20 U/ml ...

A protein was created where TDP-43 was fused to the SUMO2 protein and these fusion proteins were expressed in cells with or ...

A key enzyme and its molecular pathway are critical to keeping certain immune cells active and away from "exhaustion," ...

Q32 Bio Inc. ("Q32 Bio"), a clinical stage biotechnology company focused on developing innovative therapies for alopecia areata and other autoimmune and inflammatory diseases, today reported financial ...

In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further ...

Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory ...