Reproductive-aged women with high fasting insulin levels could be more likely to report abnormal uterine bleeding, according to data published in Menopause. In a cross-sectional study conducted at ...

The proposed pathway—about which Makary has yet to provide further details—could enable conditional approval for drugs targeting rare diseases without data from a randomized, controlled clinical trial ...

A landmark review in Nature Reviews Genetics dissects the rare and common genetic variants that shape human height. The paper explains how monogenic and polygenic factors converge on key growth ...

Mevrometostat (PF-06821497) in combination with enzalutamide for androgen receptor pathway inhibitor (ARPI)-naïve patients with metastatic castration-resistant prostate cancer (mCRPC): The phase 3, ...

Low-dose aspirin to reduce recurrence rate in colorectal cancer patients with PI3K pathway alterations: 3-year results from a randomized placebo-controlled trial.

This analysis indicates that the strategy of repeating LFTs in asymptomatic patients, advocated by current guidelines, is less sensitive and far more expensive than viral testing those patients ...

Objective Evaluation of predictive value of liver function tests (LFTs) for the detection of liver-related disease in primary care. Design A prospective observational study. Setting 11 UK primary care ...

If your doctor thinks there’s a problem with your liver, you’ll probably get a liver function test. Learn more about what the liver function test is used for, what to expect, how to prepare ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double-bl ...

These functions are regulated by the interplay of various signaling pathways. The TGF-β and HIPPO pathways are particularly relevant due to their roles in tumor suppression and liver regulation.

The iLFT cascading algorithm indicated that approximately 70% of people with an initial abnormal liver function test (LFT) could be safely managed in primary care.

Empty-handed neurons might cause neurodegenerative diseases Key pathway identified for how depletion of axonal mitochondria disrupts autophagy Peer-Reviewed Publication Tokyo Metropolitan University ...