In the 1966 novel Fantastic Journey, by Isaac Asimov, a miniature submarine and crew travel throughout the human circulatory ...

Defective endocardial Notch signaling affects cardiac valve and chamber development, leading to diseases such as bicuspid aortic valve (BAV) and LV noncompaction (LVNC) cardiomyopathy (Figure 2H and ...

Altogether our data support a role for the BMP-pSmad1/5/8 signaling cascade as a critical mechanism in the initial onset and progression of aortic valve calcification in a novel mouse model of CAVD.