Novel combination achieves 60.8% response rate and 90.2% disease control rate in first-line non-small cell lung cancer (1L ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T ...

Complementary nature of these two immunotherapies leads to excellent 17.6-month median Overall Survival in head and neck cancer patients with PD-L1 CPS 1; Mature overall survival ...

IL-21 is primarily produced by CD4+ T cells, particularly follicular helper T (Tfh ... IL-21, Interleukin-21; Tfh cells, Follicular helper T; Th17, T helper 17; MHC, Major Histocompatibility Complex; ...

When the immune system becomes activated by a virus such as HIV, part of the response includes the release of CD4 cells. Also known as helper cells, their role is to trigger the release of another ...

In this useful study, the authors tested a novel approach to eradicate the HIV reservoir by constructing a herpes simplex virus (HSV)-based therapeutic vaccine. The approach was tested in experimental ...

et al. Influence of lifelong cumulative HIV viremia on the long-term recovery of CD4+ count and CD4+/CD8+ ratio among patients on combination antiretroviral therapy. AIDS. 2015;29(5):595-607. DOI: ...

Biomarkers such as CD4, CD8, PD-L1, FOXP3, and CK AE1/3 are critical for understanding T-cell biology and tumor-immune interactions. Traditional immunofluorescence (IF) and immunohistochemistry (IHC) ...

This study presents a useful reassessment of the potential role of dendritic cell-derived IL-27 p28 cytokine in the functional maturation of CD4+CD8- thymocytes, and CD4+ recent thymic emigrants. The ...

5 Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore 6 Department of Diagnostic Radiology, Singapore General Hospital, Singapore 7 Department of Nuclear ...