Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and ...

As expected, the overall respiration rates as well as the part of the respiration devoted to ATP synthesis (respiration loss in response to triethyltin), were both increased from the highly glycolytic ...

Reactive oxygen species (ROS), produced during dopamine metabolism and mitochondrial respiration, lead to oxidative damage, while mitochondrial dysfunction exacerbates energy deficits and disrupts ...

ATP is largely produced by mitochondria, and mitochondrial functions and the rate of ATP synthesis naturally declines throughout our lifespan.

Synthetic data generation emerges as a strategy to mitigate data scarcity in digital pathology, where complicated tissue and cellular features are correlated with cancer diagnosis. The synthesis of ...

In the present work, we employ ATP synthesis measurements in a liposome model using purified enzymes, high-resolution oxygen consumption measurements in human fibroblast cells, and membrane potential ...

Mitochondria are the main site of ATP synthesis, which is produced mainly through the TCA cycle and OXPHOS, named as mitochondrial aerobic respiration (7). Under normal physiological conditions, ...

Transcriptome and proteome analyses reveal molecular determinants involved in the TCR-induced functional reprogramming and identify signalling pathways and cellular functions regulated by MCU.

Notably, with GNE-140 treatment, the basal respiration, ATP associated oxygen consumption, and maximal respiration all decreased, indicating a reduced electron flux rate through ETC.

This disrupted glycolysis led to impaired TCAC and mitochondrial respiration due to reduced pyruvate and glutamine carbon influx into TCAC. Under hypoxia, LDH inhibition had a stronger effect, ...

A molecule called adenosine triphosphate (ATP) is the basic unit of biochemical energy that fuels the activities of all cells.