T cell tolerance to self-antigens is considered to reflect a combination of central and peripheral tolerance 1,2,3,4,5.Central tolerance leads to deletion of immature T cells in the thymus and is ...

Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance.

More information: Elif Çakan et al, TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance, Journal of Experimental Medicine (2023). DOI: 10.1084/jem.20230944 .

New studies reveal that a learned compensatory response can trigger "drug tolerance," a physiological process central to addiction. Drug tolerance makes people need more and more drug to get the ...

“Central tolerance depends on a [DNA-sensing] receptor called TLR9.” Their findings were published today in the Journal of Experimental Medicine . Exploring B cells and autoimmune disorders ...

Signaling molecules involved in central tolerance were inhibited; upon closer examination, the scientists saw that this stemmed from CXCL4 binding to and preventing the delivery of DNA fragments ...

This process, known as central tolerance, is thought to be controlled by B cell receptors (BCRs) on the surface of the developing B cells.