Leg edema* Lower extremity skin changes (hemosiderosis, atrophie blanche, lipodermatosclerosis)* ... Initial clinical findings usually include dependent edema that improves with elevation.

Patients with venous disease may present with varicose veins, edema, skin changes, venous leg ulcers, or a combination thereof . Patients may be asymptomatic or have symptoms of pain, itching ...

ANGIOKERATOMA corporis diffusum universale, or Fabry's disease, was regarded as a dcrmatologie curiosity until a description by Ruiter and Pompen1 from the Netherlands in 1939 suggested that it was ...