In a new large-scale study, researchers from the Wellcome Sanger Institute, EMBL's European Bioinformatics Institute (EMBL-EBI), Open Targets, and collaborators used CRISPR gene editing to map the ...

Using the atlas, the authors mapped the transcriptional profiles of more than 1.2 million cells from 318 patients with leukemia to distinct cell states. The cohort chiefly consisted of patients ...

TripletDGC, an open-source GitHub toolkit, leverages single-cell RNA-seq to map nearly 10,000 disease-associated genes to their most impacted cell types—creating over 54,000 gene-disease-cell links to ...

REC-1245 is a selective degrader of RBM39, a new target, identified by Recursion’s AI-enabled Maps of Biology platform, with a similar biological function to the well-known but hard-to-drug ...

A potential target for experimental drugs that block PRMT5 - a naturally occurring enzyme some tumors rely more on for ...

1 Source: Guengerich FP. Mechanisms of drug toxicity and relevance to pharmaceutical development. Drug Metab Pharmacokinet. 2011;26 (1):3-14. doi: 10.2133/dmpk.dmpk ...

To estimate how far drug-induced changes occur from their intended metabolic targets, the researchers systematically treated cancer cells with around 350 drugs that target different enzymes, selected ...

Drug-delivering aptamers that can precisely target leukemia stem cells with enhanced potency have been developed. Delivering anticancer drugs with specificity and potency to cancer stem cells is an ...