Hence, how loss of cell polarity in epithelial cells may promote epithelial mesenchymal transition and metastasis will also be discussed.

Casarsa C, Bassani N, Ambrogi F, Zabucchi G, Boracchi P, Biganzoli E, et al. Epithelial-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma.

Background: Tumor cells that have undergone an epithelial-to-mesenchymal (EMT)-like phenotypic transformation in situ have been implicated in tumor cell invasiveness and disease progression.

The study is published in the journal Cell Metabolism. More information: Xiaolong Zhu et al, Acetate controls endothelial-to-mesenchymal transition, Cell Metabolism (2023).

Shifting cell states in health and disease The shift from a stationary cell state with specialized functions to a more migratory cell state is called the epithelial-to-mesenchymal transition, or EMT. ...