The natural protein universe is vast, and yet, going beyond and designing new proteins not observed in nature can yield new ...

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in ...

In a study published in Nature Metabolism, researchers at the University of Michigan found that mitochondria also accumulate misfolded proteins, which kills β-cells.

Protein folding is the process by which proteins achieve their mature functional (native) tertiary structure, and often begins co-translationally. Protein folding requires chaperones and often ...

Technological advances in proteomics, including sample separation, mass spectrometry, and searching algorithms, have empowered in-depth discovery of protein post-translational modifications from ...

Proteins that fold over free-energy barriers ≤ 3RT are classified as downhill folders. This regime is characterized by equilibrium unfolding that is proportionally broader and more complex the lower ...

Here, we describe an all-atom protein generative model, Protpardelle, which codesigns the backbone, sequence, and sidechains of a protein together. Our method enables a key capacity in protein design: ...