A new AI tool that models how variations in peptides change T cell receptor binding could help design immunotherapies with ...

The combination of interleukin-2 (IL-2) agonism with programmed cell death protein 1 (PD-1) checkpoint inhibition has ...

Interleukin-2 (IL-2) inhibitors are immunosuppressive agents that block the activity of IL-2, a cytokine involved in the activation and proliferation ...

Researchers from UCLA published a Perspective in Science Bulletin proposing bioengineered platforms that mimic immunological synapses to improve CAR-T cell manufacturing. Their strategies offer ...

Following pro-inflammatory activation of myeloid cells co-cultured with Tregs, the addition of COYA 301 (LD IL-2) alone enhanced Treg suppressive function by 15%.

Patients receiving the GPC3-CAR T cells armed with IL-15 had a higher incidence of cytokine release syndrome. Those symptoms were quickly resolved with activation of the inducible caspase 9 safety ...

The study concludes that repeated SARS-CoV-2 vaccinations, as recommended for vulnerable people and healthy populations, do not induce T-cell exhaustion or compromise T-cell function. Download ...

Interleukin-18 enhances the activation of T cells and natural killer cells, promotes the production of interferon-γ, and has potential therapeutic applications. 18-20 Preclinical studies ...