An elderly man with immunoglobulin G4-related disease (IgG4-RD) with kidney involvement and monoclonal gammopathy was successfully treated with corticosteroid therapy.

Arialys Therapeutics' precision medicine has shown preclinical potential to address the underlying cause of anti-NMDA receptor encephalitis (ANRE), a rare brain disorder that comes with severe ...

Key takeaways: B-cell depletion with inebilizumab reduced flare risk for pancreatic and/or biliary IgG4-related disease. It also reduced overall glucocorticoid use for disease control in both ...

IgG4-RD is an immune-mediated disorder. When someone has it, their immune system goes into overdrive, producing more antibodies (or immunoglobulins, hence the name) than necessary that disrupt ...

This is the first and only treatment approved for this rare autoimmune disease in the United States. An estimated 200,000 people in the United States are living with IgG4-RD, according to a press ...

The modulation of macrophage polarization by IgG1 and IgG4 may have significant implications for cancer progression and the response to immunotherapy. Our findings underscore the importance of further ...

About Timberlyne Therapeutics Timberlyne Therapeutics is a clinical-stage biopharmaceutical company focused on the development and commercialization of transformational therapies for high unmet ...

IgG4-related disease is a multiorgan, relapsing, fibroinflammatory, immune-mediated disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B cells and may be effective for treat ...

A 45-year-old woman was evaluated in the rheumatology clinic because of possible IgG4-related disease. She had polyclonal hypergammaglobulinemia, as well as kidney and bone lesions. A diagnosis was ...

Conclusions Hypocomplementaemia in IgG4-RD is not unique to patients with renal involvement and may reflect the extent of disease. IgG1 independently correlates with hypocomplementaemia in IgG4-RD, ...

Phase I study of CN201, a novel CD3xCD19 IgG4 bispecific antibody, in adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia.. If you have the appropriate software installed, ...