This disease is IgG4 related. There is substantial interest ... Recently, a new class of therapeutics that disable the neonatal Fc receptor (FcRn), which protects IgG from degradation, has emerged ...

Beamon set out on a journey, and 26 doctors, 37 procedures and more than 17 years later, a rheumatologist finally cracked the confounding code: She had immune disorder IgG4-related disease ...

Given the dynamic nature of IgG1 Fc domains, we would need larger numbers of structures to confidently characterize the efficacy of GCCD matrix classification of experimental data. This work focuses ...

ANKTIVA is a first-in-class IL-15 agonist IgG1 fusion complex, consisting of an IL-15 mutant (IL-15N72D) fused with an IL-15 receptor alpha, which binds with high affinity to IL-15 receptors on NK ...

1 Enhertu is a specifically engineered HER2-directed DXd antibody drug conjugate. Its mechanism of action involves the humanized anti-HER2 IgG1 antibody trastuzumab attaching by a cleavable linker to ...

The transfer of maternal IgG to the fetal blood circulation is an active Fc-receptor-mediated transport ... transport of IgG1 is predominant. The transport capacity of IgG1–4 is in the following ...

(Getty Images) In the past few years alone, researchers have reported myriad cases of IgG4-RD being mistaken for some type of malignancy. IgG4-RD can affect nearly any organ system in the body and ...

None of the cases exhibited positive IgG4 plasma cells or MDM2 amplification. Table 1. Clinicopathologic features of all reported cases of the perinephric myxoid pseudotumors of fat. At present, the ...