In a preprint recently featured in SSRN, researchers introduced an innovative machine learning framework aimed at improving the diagnosis of immunoglobulin G4-related disease (IgG4-RD). The proposed ...

It consists of a human IgG1 monoclonal antibody conjugated to a potent camptothecin-based TOP1i payload with a protease-cleavable linker, achieving an average DAR of 8. These promising preclinical ...

She exhibited elevated IgG4 levels and was diagnosed with IgG4-related ophthalmic disease. Treatment with low-dose glucocorticoids slightly improved her clavicular symptoms. However, over the past ...

This disease is IgG4 related. There is substantial interest ... Recently, a new class of therapeutics that disable the neonatal Fc receptor (FcRn), which protects IgG from degradation, has emerged ...

Beamon set out on a journey, and 26 doctors, 37 procedures and more than 17 years later, a rheumatologist finally cracked the confounding code: She had immune disorder IgG4-related disease ...

Given the dynamic nature of IgG1 Fc domains, we would need larger numbers of structures to confidently characterize the efficacy of GCCD matrix classification of experimental data. This work focuses ...

ANKTIVA is a first-in-class IL-15 agonist IgG1 fusion complex, consisting of an IL-15 mutant (IL-15N72D) fused with an IL-15 receptor alpha, which binds with high affinity to IL-15 receptors on NK ...