Liver transplant is the standard-of-care for patients with end-stage liver disease and is the second most common solid-organ transplant after the kidney, the authors explained.

Results In this study we have used a multi-modal approach to uncover gene regulatory networks (GRNs) driving cell state transitions in human liver disease. Data integration from single nuclei snRNA, ...

In fatty liver disease, for example, blocking access to pyruvate entry into mitochondria could encourage the body to use potentially dangerous fat that has been stored in liver cells.

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

A new study reveals that ammonia, a toxin accumulating in liver disease patients, directly harms liver cells by damaging mitochondria. This creates a vicious cycle, leading to severe health ...

Discover how liver cancer evades the body's natural defenses and explore the link between fatty liver disease and increased cancer risk.

Histotripsy treatment is an FDA-approved therapy that kills cancer cells using sound and water. Providence Mission Hospital is leading the charge.

The aging and failure of cells that occurs when the liver is damaged can spread to other organs, suggests a new study in mice and humans from researchers at UCL, the University of Edinburgh and ...

Their findings, entitled “ Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch,” were published in Cell on October 29, 2024.

Renal cell carcinoma (RCC) is one of the 10 most commonly diagnosed solid tumors. Most RCCs are histologically defined as clear cell, comprising approximately 75% of diagnoses. However, the remaining ...

Renal cell carcinoma (RCC) is one of the 10 most commonly diagnosed solid tumors. Most RCCs are histologically defined as clear cell, comprising approximately 75% of diagnoses. However, the remaining ...

The newly-discovered cells help shed light on how the liver repairs itself after damage.