AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress.

The inhibitory effects of kinase signalling pathways, including PI3K and MAPK, on VA extract and VA-derived compounds have been reported previously (Liu et al., 2022; Takahashi, 2011; Wu et al., 2022) ...

The Mitogen-Activated Protein Kinases (MAPK) pathway plays a pivotal role in regulating cell proliferation, migration, and invasive capacity in response to extracellular stimuli. This review focuses ...

MAP2K1/MEK1 mutations are potentially actionable drivers in cancer. MAP2K1 mutations have been functionally classified into three groups according to their dependency on upstream RAS/RAF signaling.

Conserved signaling modules known as mitogen-activated protein kinase (MAPK) link extracellular stimuli to the regulatory apparatus, controlling vital cellular processes such as migration, apoptosis, ...

Our findings position FAIM2 as a novel negative regulator of pathological cardiac hypertrophy through its inhibitory action on mitogen‐activated protein kinase signaling activation. This ...

The authors have used genetic and environmental stress conditions to modulate MAP kinase signalling and demonstrate their effect on APC/C activation. This work provides evidence for the role of MAP ...

Significance Kinases are molecular switches for cellular signaling. Many kinases are switched on by phosphorylation of their dynamic activation loops and are turned off by protein phosphatases that ...

STPKs play critical roles in signalling pathways, such as the transforming growth factor-beta pathway and the mitogen-activated protein kinase (MAPK) pathway. They can be further subdivided into ...