Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs ...

Abstract. The anti-EGFR agents cetuximab and panitumumab were the first targeted agents to be licensed for colorectal cancer and marked a significant advancement in personalized care. Initial ...

Regulation of the immune response is crucial for avoiding an excessive inflammatory response. Here, recent advances in our understanding of the regulation of mitogen-activated protein kinase (MAPK ...