This study provides valuable insights into the crosstalk between ATG2A with components of the early secretory pathway, namely RAB1A and ARFGAP1. The evidence supporting the claims is convincing.

Herein, we construct an oligonucleotide-based bioorthogonal platform to intervene in the crosstalk between the cGAS-STING pathway and autophagy, thereby achieving enhanced immunotherapy. In the ...

Autophagy, traditionally known for degrading and recycling cytoplasmic components to maintain cellular homeostasis, has recently emerged as a novel route for the unconventional secretion of ...

The researchers specifically inhibited autophagy genes functioning at each step of the process in the neurons of the animals, and found that neuronal inhibition of early-acting, but not late ...

Here, we summarize current knowledge of the autophagy-related UPS pathways, describing and comparing diverse features in the autophagy-related UPS cargos and autophagy machineries utilized in UPS.

Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic aggregates can increase ...

Autophagy and apoptosis are functionally distinct mechanisms for cytoplasmic and cellular turnover. While these two pathways are distinct, they can also regulate each other, and central components of ...

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease ...

Autophagy is a macromolecular degradation pathway that is activated in response to stress, including ER stress, but the mechanism by which it is regulated is still unclear. Here, we describe a ...

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this ...