Immune checkpoint blockade (ICB) therapies have revolutionized cancer treatment, yet many tumors remain resistant. Now, ...

The first patient with Cyclin E1+ platinum-resistant ovarian cancer has been dosed with azenosertib in part 2a of the phase 2 DENALI clinical trial.

Simultaneous cyclin D1 overexpression and p27 kip1 knockdown enable robust Müller glia cell cycle reactivation in uninjured mouse retina eLife 13:RP100904.

p27 as a tumor-suppressor protein. a , In normal epithelial cells, anti-mitogenic signals, such as TGF- or IL-6, act to inhibit growth. They do so by mobilizing p27 to inhibit cyclin E-cdk2. This ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz ...

Circle Pharma Announces Preclinical Data Poster Presentation of CID-078, a First-and-Only-in-Class Cyclin A/B RxL Inhibitor at the 2024 World Conference on Lung Cancer ...

The CIP–KIP family includes p21 CIP1, p27 KIP1 and p57 KIP2, which inhibit the kinase activity of the G1 Cdk2–cyclin A and Cdk2–cyclin E complexes and thus prevent G1–S phase transition.

The cdk inhibitor p27 is highly expressed in contact-inhibited but not proliferating ECs, whereas the level of cyclin A protein is preferentially expressed in proliferating ECs. p27 protein was ...

UBE2G1 had robust in vitro chain extension activity with SCF, and UBE2G1 knockdown in cells lacking UBE2R1/2 resulted in stabilization of the SCF substrates p27 and CYCLIN E as well as the CUL2-RING ...

To mediate the progression of G1 checkpoint, PIN1 activates cyclin D1-CDK4/6 through inactivation of retinoblastoma protein (Rb) and accumulation of cyclin D1 protein. PIN1 is able to promote G1-S ...

Somatic inactivating variants in the gene CDK12, encoding cyclin-dependent kinase 12, generate fusion-induced neoantigens in prostate cancer. This finding supports the hypothesis that prostate canc ...

Cell cycle proteins cyclin E, p27, Rb, and E2F1 exhibit different levels of lineage-specific expression patterns in embryonic cells, adult normal pituitary, and corticotroph adenoma (Table 1). Table 1 ...