Untreated hypothyroidism can lead to symptoms like fatigue, weight gain, constipation, and dry skin. Over time, it can cause serious complications. Learn more.

The pathogenesis of tendinopathy and the primary biological change in the tendon that precipitates pathology have generated several pathoaetiological models in the literature. The continuum model of ...

In rare cases, people with Graves’ disease can have thickening and darkening of the skin on the shins or the tops of the feet, which is called Graves’ dermopathy or pretibial myxedema. [8] ...

Cutting off orexin also tempered tau pathology, dialing down phosphorylation at serines 202 and 409, and threonine 205 relative to Zolpidem or vehicle treatment (image below). Fade Away, Phospho-Tau.

Graves’ disease: Diagnosed based on the association of hyperthyroidism with diffuse and vascular goiter, acquired exophthalmos, pretibial myxedema, and TRAK positivity. Hashimoto’s thyroiditis: ...

Some people with hyperthyroidism may develop a skin rash called pretibial myxedema. Learn more about this condition.

While there are reports of local trauma clearly contributing to the pathogenesis of pretibial myxedema, direct evidence for a similar mechanism in Graves' ophthalmopathy (GO) has been lacking.

Pathology is a microscopy-intensive discipline. Experts prepare, stain and image thin sections of tissue under a microscope in order to assess the presence ...

Major driver of inflammatory pathology in autoimmune and chronic inflammatory diseases Date: February 6, 2025 Source: Mass General Brigham Summary: Researchers discovered a previously unknown ...

CIRCUMSCRIBED pretibial myxedema is an unusual but not a particularly rare skin disease. In an excellent article Curtis and his associates1 described this condition, and many cases have been report ...

Digital pathology is reshaping how labs operate by replacing traditional paper-based systems and manual workflows with advanced digital technology.