Untreated hypothyroidism can lead to symptoms like fatigue, weight gain, constipation, and dry skin. Over time, it can cause serious complications. Learn more.

In rare cases, people with Graves’ disease can have thickening and darkening of the skin on the shins or the tops of the feet, which is called Graves’ dermopathy or pretibial myxedema. [8] ...

Panelists discuss how the pathophysiology of pulmonary arterial hypertension involves complex mechanisms across multiple genetic and treatment pathways, with over 20 identified genes and four ...

While there are reports of local trauma clearly contributing to the pathogenesis of pretibial myxedema, direct evidence for a similar mechanism in Graves' ophthalmopathy (GO) has been lacking.

CIRCUMSCRIBED pretibial myxedema is an unusual but not a particularly rare skin disease. In an excellent article Curtis and his associates1 described this condition, and many cases have been report ...

SEATTLE — Hospitalized adults with hypothyroidism who are diagnosed with myxedema coma have a higher mortality rate and are hospitalized for longer than those without myxedema coma, according to ...

Pictures of hyperthyroid rash The slideshow below includes examples of pretibial myxedema, which may occur in people with hyperthyroidism.

Despite the suspected shared pathophysiology of TED and PTM, the effect of teprotumumab on PTM has not been formally studied. The authors retrospectively assessed response to treatment in a cohort of ...

Myxedema coma is a rare but life-threatening condition. People with hypothyroidism who are in or near a coma should be taken to an emergency department immediately.

Motor neurone disease is a progressive degenerative disorder affecting specialist nerve cells called motor neurons that control muscle movement.

The exact mechanism of how mesothelioma, which is a highly aggressive tumor with a dismal prognosis, develops remains unclear.

Cardiomyopathy: Epidemiology, Etiology, and Pathophysiology — A brief guide through the wide range of cardiomyopathies ...