Bacterial cell division, a process wherein a single cell divides to form two identical daughter cells, represents one of the ...

EMBL-EBI scientists and collaborators at Heidelberg University have developed CORNETO, a new computational tool that uses ...

This protocol refines co-immunoprecipitation (co-IP) for lipid droplet (LD)-specific protein interactions by isolating ...

Liquid–liquid phase separation (LLPS) is a process by which biomacromolecules, particularly proteins, condense into a dense phase that resembles liquid droplets. Dysregulation of LLPS is implicated in ...

Advancements in artificial intelligence (AI) are dramatically transforming the field of protein science, offering powerful tools to tackle its longstanding ...

The chaperonin TCP-1 ring complex (TRiC), also known as chaperonin-containing TCP-1 (CCT) complex, plays a crucial role in protein folding and quality control within the cell. Comprising eight ...

Cryo-electron microscopy and high-speed atomic force microscopy analyses of an epilepsy-related ligand–receptor complex LGI1–ADAM22 reveal the three-dimensional structure and dynamics of the 3:3 ...

Covalent labeling (CL) mass spectrometry is a versatile structural technique for elucidating structural information about proteins, including protein–protein complexes. When integrated with ...

AlphaFold-guided in vitro and in vivo analyses establish the mechanism of ULK complex formation and provide a structural basis for understanding its role in mammalian autophagy initiation.