TREM2, a cell surface receptor on monocyte-derived alveolar macrophages (Mo-AMs), is highly expressed in fibrotic lungs and promotes macrophage survival and lung fibrosis by delaying apoptosis.

Looking specifically at alveolar macrophage cells under a microscope, the researchers measured the sizes of the cells and the amount of carbon accumulated in the cells. They found that the average ...

Our lead program, molgramostim inhalation solution, is an inhaled granulocyte-macrophage colony-stimulating factor (GM-CSF) in Phase 3 development for autoimmune pulmonary alveolar proteinosis (aPAP).

The study found that COPD patients’ alveolar macrophages — a type of lung cell that removes dust, particles and microorganisms from the lungs — contain more carbon than those of smokers. The ...

James Baker, Sophie Booth, Josiah Dungwa, Andrew Higham, Dave Singh, Simon Lea. Alveolar macrophage carbon is associated with COPD severity. ERJ Open Research , 2025; 00933-2024 DOI: 10.1183 ...

More information: Huachun Cui et al, TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity, Nature Communications (2025). DOI: 10.1038/s41467-025-57024-0 ...