In normal cells, genomic lesions occur naturally during DNA replication as part of the cell cycle, ... telomere DNA-ADPr is highly dynamic and subject to stringent control by TARG1. ...

When copying the telomere, leading-strand DNA replication should copy the CCCTAA repeats to generate the TTAGGG repeat strand, while lagging-strand synthesis should do the opposite, making new ...

Telomeres play an essential role in determining how many times a cell can divide. These repetitive sequences of DNA are located at the ends of chromosomes, structures that contain genetic information.

Wistar Institute have published the first detailed report on the structure and function of a crucial domain in the protein known as Cdc13, which sustains telomeres by clamping to DNA and ...

A s DNA strands ravel and unravel in an intricate dance, one notable event takes center stage: replication. This process is essential to life, but the finer details of its orchestrated steps are still ...

In normal cells, genomic lesions occur naturally during DNA replication when a cell divides, ... leading to disruption of telomere replication and premature telomere shortening.

Imagine your DNA as a set of shoelaces. Telomeres are like the plastic tips at the ends of those shoelaces, preventing them from fraying and unraveling. Structurally, telomeres are repetitive ...

To show that these telomere defects were due to modification of telomeric DNA, O'Sullivan and his team took bacterial enzymes that function similarly to PARP1 and put them into human cells.

Find out what telomeres are and how to hack your DNA to slow down the aging process, from the authors of The Telomere Effect. Health Mental Health Published Jan 10, 2017 ...

For the first time, scientists have shown that a major protein acts as a direct block in multiple stages of DNA replication, improving our understanding of how cancer develops. Researchers studied the ...