A key enzyme and its molecular pathway are critical to keeping certain immune cells active and away from "exhaustion," ...

In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further ...

Dynamic remodeling of the endomembrane system is a core biological process essential for maintaining cellular ...

SIRT2, an enzyme previously overlooked in astrocytic GABA production, may be crucial for distinguishing the specific effects ...

CD4 T helper cells are a type of white blood cell called a lymphocyte that serves an important role in your immune system. These cells help defend the body against infection by directing other "killer ...

Analysis of GR-null kidney extracts demonstrates reduced levels of pERK and SUFU identifying potential cell pathway crosstalk with GR signalling that coordinately regulate ciliogenesis in the renal ...

Department of Ophthalmology, Tongji Hospital Affiliated with Tongji University, Shanghai 200065, People’s Republic of China ...

Functional assays including cell proliferation, scratch wound, tube formation, NO content detection, and senescence‐associated β‐galactosidase staining were conducted. RNA sequencing was performed to ...

A pinched nerve occurs when there is pressure or force on an area of a nerve, causing it to send pain signals to the brain. Most cases are mild, and a person can often treat them at home. In this ...

Moreover, single-cell RNA-sequencing analysis indicated increased Th2 cells and interleukin 13 expression, along with decreased innate lymphoid cells and upregulated proinflammatory cytokines.