Purine nucleoside phosphorylase (PNP) and hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) catalyze N-ribosidic bond cleavage in purine nucleosides and nucleotides, with addition of phosphate ...

The binding of [5‘-3H]inosine to human purine nucleoside phosphorylase results in an equilibrium binding isotope effect (BIE) of 1.5%, and transition state formation causes an intrinsic KIE of 4.7%.

Texas has pledged public money to research ibogaine, hoping for FDA approval to aid veterans with PTSD and addiction.

A computational method for finding transition states in chemical reactions, greatly reducing computational costs with high reliability, has been devised. Compared to the most widely used existing ...

Scientists often call critical geometry in reactions a transition state. This state has an almost incomprehensibly short lifetime of less than one millionth of one millionth of a second.

Chemists have devised a technique that allows them to determine the structure of the transition state of a reaction by observing the products that result from the reaction.

The cytoplasm behaves as an adaptable fluid that can reversibly transition into a protective solid-like state upon stress.

During chemical reactions, molecules pass through a transition state — an unstable, high-energy form that immediately changes into the final product.

The binding transition state (TS) is the rate-limiting step for transient molecular interactions. This important step in the molecular recognition process, however, is largely understood only at a ...